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Related Concept Videos

Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...

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Updated: Jun 6, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

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Published on: March 20, 2015

Inkjet printed surface enhanced Raman spectroscopy array on cellulose paper.

Wei W Yu, Ian M White

    Analytical Chemistry
    |November 10, 2010
    PubMed
    Summary

    Researchers developed an ultra low-cost surface-enhanced Raman spectroscopy (SERS) substrate using inkjet-printed nanoparticles on cellulose paper. This innovation enables rapid, on-demand chemical and biomolecular detection for lab and field applications.

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    Fabrication of polydimethylsiloxane (PDMS)-Based Flexible Surface-Enhanced Raman Scattering (SERS) Substrate for Ultrasensitive Detection
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    Microembossing: A Convenient Process for Fabricating Microchannels on Nanocellulose Paper-Based Microfluidics
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    Microembossing: A Convenient Process for Fabricating Microchannels on Nanocellulose Paper-Based Microfluidics

    Published on: October 6, 2023

    Area of Science:

    • Materials Science
    • Analytical Chemistry
    • Nanotechnology

    Background:

    • Micro/nanofabrication of surface-enhanced Raman spectroscopy (SERS) substrates is crucial for chemical and biomolecular analysis.
    • High production costs and limited shelf-life hinder the widespread adoption of current SERS substrates.
    • Paper-based microfluidic systems offer a promising low-cost, disposable platform for biosensing.

    Discussion:

    • This study presents a novel, ultra low-cost SERS substrate fabricated using a consumer inkjet printer on cellulose paper.
    • Surface modification renders hydrophobic sensing regions, concentrating analytes via capillary action.
    • Silver nanoparticles are precisely patterned into arrays on the hydrophobic paper, forming the SERS sensing platform.

    Key Insights:

    • Demonstrated SERS detection of Rhodamine 6G dye down to 10 femtomoles in 1 microliter.
    • The technique allows for immediate, on-demand SERS microarray construction prior to sample analysis.
    • Achieved microscale precision in nanoparticle patterning using inkjet printing technology.

    Outlook:

    • Potential for widespread adoption in routine laboratory analysis and point-of-sample field testing.
    • Facilitates ultra low-cost chemical and biomolecular detection in diverse settings.
    • Opens avenues for disposable, highly sensitive analytical devices for various applications.