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Glycaemic variability is associated with coronary artery calcium in men with Type 1 diabetes: the Coronary Artery

J K Snell-Bergeon1, R Roman, D Rodbard

  • 1Barbara Davis Center for Childhood Diabetes, School of Medicine, University of Colorado Denver, Aurora, CO, USA.

Diabetic Medicine : a Journal of the British Diabetic Association
|November 10, 2010
PubMed

Insights

Subclinical atherosclerosis, indicated by coronary artery calcium, is linked to glucose levels and variability in men with Type 1 diabetes. This association was not observed in women, suggesting potential gender differences warrant further investigation.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Diabetes Research

Background:

  • Type 1 diabetes (T1D) is associated with an increased risk of cardiovascular disease.
  • Subclinical atherosclerosis, such as coronary artery calcium (CAC), is an early marker of cardiovascular risk.
  • Understanding the relationship between glycemic control and atherosclerosis in T1D is crucial for risk stratification and prevention.

Purpose of the Study:

  • To investigate the association between coronary artery calcium and glycemic control (glucose levels and variability) in adults with T1D.
  • To explore potential gender differences in this association.

Main Methods:

  • Coronary artery calcium was measured using electron beam tomography in 75 adults with T1D.
  • Continuous glucose monitoring (3-5 days) provided data on mean glucose levels and glycemic variability (sd(T), sd(dm), sd(hh:mm)).
  • Logistic regression analysis was used to assess associations between CAC and glycemic parameters, stratified by gender.

Main Results:

  • Significant associations were found between CAC and several glycemic parameters (mean glucose, % values > 10 mmol/l, % values < 3.9 or > 10 mmol/l, sd(T), sd(dm), sd(hh:mm)) in men.
  • No significant associations between CAC and glycemic parameters were observed in women.
  • Odds ratios for these associations in men ranged from 4.0 to 6.0.

Conclusions:

  • Subclinical atherosclerosis is associated with glucose levels and variability in men with Type 1 diabetes.
  • The findings highlight potential gender-specific differences in the relationship between glycemic control and cardiovascular risk in T1D.
  • Further research is warranted to elucidate the mechanisms underlying these associations and gender differences.
Abstract

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