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Cerebral Hemispheres

Cerebral Hemispheres

The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...

Cerebrum: Anatomical Overview II

Cerebrum: Anatomical Overview II

Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...

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Updated: Jun 6, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Corpus callosum volume and interhemispheric transfer in multiple sclerosis.

L N Brown¹, Y Zhang, J R Mitchell

¹Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques

|November 10, 2010

Summary

In multiple sclerosis (MS) patients, smaller corpus callosum (CC) volume correlates with higher tactile temporal thresholds. This suggests CC measurements may help track disease progression and treatment efficacy.

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

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Published on: July 28, 2013

Area of Science:

Neuroscience
Neurology
Medical Imaging

Background:

The corpus callosum (CC) is frequently affected in multiple sclerosis (MS).
Assessing CC structure and function could aid in monitoring MS progression.
Bimanual tactile temporal thresholds rely on interhemispheric transfer via the CC.

Purpose of the Study:

To investigate the correlation between corpus callosum volume and bimanual tactile temporal thresholds in MS patients.
To explore potential imaging biomarkers for MS progression.

Main Methods:

Thresholds were measured in MS patients and matched controls.
Magnetic resonance (MR) imaging was used to assess CC volume.
A semiautomatic livewire algorithm was employed for CC volume assessment.

Main Results:

MS patients exhibited significantly smaller CC volumes (21% reduction) and higher thresholds (49% increase) compared to controls.
A significant negative correlation (r = -0.66, p = 0.01) was found between CC volume and tactile temporal thresholds in MS patients.

Conclusions:

Reduced CC volume and altered tactile temporal thresholds are associated in MS.
These measures, reflecting interhemispheric transfer, show promise as outcome measures for MS therapies.
Further research is warranted to develop models for measuring recovery in MS.