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Multiple Sclerosis l: Introduction

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Related Experiment Video

Updated: Jun 6, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

Multiple sclerosis - a vascular etiology?

¹Department of Surgery, University of Chicago, Illinois, USA. bkaweir@shaw.ca

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques

|November 10, 2010

Summary

Investigating venous circulation in multiple sclerosis (MS) revealed potential obstructions. Correcting these blockages may offer clinical improvement for MS patients.

Area of Science:

Neurology
Vascular Medicine

Background:

Perivenular demyelination is a hallmark of multiple sclerosis (MS).
Recent hypotheses link MS pathology to venous flow obstructions or valve insufficiency in major veins, potentially causing cerebral and spinal cord circulatory issues.

Purpose of the Study:

To investigate the association between abnormal venous circulation and multiple sclerosis (MS).
To explore the potential therapeutic benefits of addressing venous obstructions in MS patients.

Main Methods:

Utilized non-invasive sonography and invasive venography to assess venous circulation in multiple sclerosis (MS) patients.
Investigated endovascular ballooning to open obstructed venous pathways.

Main Results:

Demonstrated abnormal venous circulation in a subset of multiple sclerosis (MS) patients.

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Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

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Observed temporary clinical improvement or stabilization in some patients following endovascular procedures to relieve venous obstructions.

Conclusions:

Abnormal venous circulation may play a role in multiple sclerosis (MS) pathogenesis.
Further validation of increased venous obstruction prevalence in MS is needed.
Angioplasty or stenting could be considered for selected MS patients if venous obstructions are confirmed.