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Generation of Local CA1 γ Oscillations by Tetanic Stimulation
Published on: August 14, 2015
Oxcarbazepine does not suppress cortical spreading depression
Ulrike Hoffmann1, Ergin Dileköz, Chiho Kudo
1Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.
Cephalalgia : an International Journal of Headache
|November 10, 2010
Summary
Oxcarbazepine did not suppress cortical spreading depression (CSD) in rats, unlike valproate. This confirms CSD as a therapeutic target for migraine prophylaxis and validates preclinical screening models.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Cortical spreading depression (CSD) is the basis of migraine aura and may trigger headache.
- CSD is implicated as a common therapeutic target for migraine prophylaxis.
Purpose of the Study:
- To evaluate spreading depression susceptibility as a preclinical drug screening tool.
- To test oxcarbazepine, an anti-epileptic drug not effective in migraine prophylaxis, for its effect on CSD.
Main Methods:
- Rats were used to measure cortical spreading depression susceptibility.
- Methods included topical KCl application and electrical stimulation.
- Oxcarbazepine and valproate (positive control) were administered.
Main Results:
- Oxcarbazepine did not suppress CSD after single or chronic dosing.
- Valproate suppressed CSD only after chronic dosing, not single dose.
- Results indicate valproate's effectiveness is dose and time-dependent.
Conclusions:
- These findings support CSD as a valid target for migraine prophylaxis.
- The study demonstrates the predictive value of CSD models for drug screening.
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