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Updated: Jun 6, 2026
09:11
Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
Pazopanib in renal cell carcinoma
James E Ward1, Walter M Stadler
1University of Chicago, Chicago, Illinois 60637, USA.
Summary
Pazopanib, a targeted therapy, significantly improved progression-free survival in advanced renal cell cancer patients. This oral medication offers a new treatment option for this patient population.
Area of Science:
- Oncology
- Pharmacology
Background:
- Pazopanib is an oral, multitargeted tyrosine kinase inhibitor.
- It is approved by the U.S. Food and Drug Administration for advanced renal cell cancer.
- It targets VEGF receptors (VEGFR).
Purpose of the Study:
- To outline the mechanism of action, preclinical and clinical data of pazopanib.
- To compare pazopanib with other drugs in its class.
Main Methods:
- Randomized, double-blind, placebo-controlled, phase III trial.
- Once daily oral dosing of 800 mg pazopanib.
Main Results:
- Pazopanib resulted in progression-free survival of 9.2 months versus 4.2 months (P < 0.0001).
Conclusions:
- Pazopanib is a clinically available VEGFR-targeted drug for advanced clear cell renal cell cancer.
- Pazopanib offers a significant survival benefit in this patient group.
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