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Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

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As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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Related Experiment Video

Updated: Jun 6, 2026

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
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Platelet function measured using a whole blood aggregometer can predict bleeding events.

Akinori Sairaku1, Yukiko Nakano, Shin Eno

  • 1Department of Cardiology, Chugoku Workers Compensation Hospital, Kure, Japan. rjrgw059@ybb.ne.jp

Journal of Atherosclerosis and Thrombosis
|November 10, 2010
PubMed
Summary

Low platelet function, measured by aggregometry, predicts bleeding complications in patients on antiplatelet therapy. This finding aids in identifying individuals at higher risk for bleeding events.

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Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Area of Science:

  • Cardiology
  • Hematology
  • Clinical Pharmacology

Background:

  • Antiplatelet therapy is crucial for preventing thrombotic events.
  • Excessive platelet function suppression can lead to increased bleeding risk.
  • Predicting bleeding complications in patients on antiplatelet agents is clinically significant.

Purpose of the Study:

  • To investigate whether platelet function measurements can predict bleeding events.
  • To determine if low platelet function is associated with increased bleeding complications.

Main Methods:

  • 743 subjects underwent platelet function testing using a whole blood aggregometer.
  • 551 subjects (74.2%) were on antiplatelet agents.
  • Bleeding and ischemic events were prospectively monitored during follow-up.

Main Results:

  • A platelet aggregation rate below 20% induced by adenosine diphosphate (ADP) was significantly associated with more bleeding events (11.9% vs. 5.2%, p=0.0007).
  • Independent predictors of bleeding events included age > 75 years, estimated glomerular filtration rate < 60 ml/min/1.73 m², and aggregation rate < 20% induced by ADP.
  • Low platelet function (aggregation rate < 20%) was a significant independent predictor of bleeding events (HR, 2.18; p=0.0071).

Conclusions:

  • Low platelet function, assessed by whole blood aggregometry, independently predicts bleeding complications.
  • Platelet function testing can aid in risk stratification for bleeding in patients receiving antiplatelet therapy.