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Updated: Jun 6, 2026

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
Conversional studies towards taxoids from C(19)-diterpenoid alkaloids by the BAC sequence
Hong Ji1, Qiao-Hong Chen, Meng Zhu
1Department of Chemistry of Medicinal Natural Products, West College of Pharmacy, Sichuan University, Chengdu, China.
Abstract:
The conversional synthesis of taxoids by the BAC sequence from the C(19)-diterpenoid alkaloids, 14-acetyltalatisamine (1), yunaconitine (12), and 14-acetylchasmanine (19), was designed and explored. Two aconane-type diterpenes 17 and 28, the advanced intermediates for our conversional synthesis, were synthesized. The key steps include the rupture of the C(7)-C(17) bond, the formation of imine, and the denitrogenation.
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