Related Experiment Video
Updated: Jun 6, 2026

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
Published on: July 27, 2022
[Measures of local non-specific resistance during of colon dysbiosis]
Aim:
To study several parameters of local non-specific resistance during development of experimental dysbiosis caused by administration of wide spectrum antibiotic.
Materials And Methods:
Objects of the study were colonocytes and coprofiltrates from 120 outbred mice developing experimental dysbiosis, in which activity of antioxidant enzymes (superoxid dismutase [SOD] and catalase) and level of one of the final product of lipid peroxidation--malondialdehyde (MDA).
Results:
Decrease of SOD and catalase activity and significant increase of MDA level during development of experimental dysbiosis were established, which were associated with decreased activity of oxygen-dependent bactericidal systems of colonocytes and changes in composition of colon microbiocenosis.
Conclusion:
It was suggested that changes in parameters of local non-specific resistance could be one of mechanisms, which cause alteration of microbiocenosis composition during colon dysbiosis.
Related Concept Videos
Dysbiosis of the Gut Microbiota
Microbiota of the Large Intestine
Microbiota of the Stomach and Small Intestine
Inflammatory Bowel Disease II: Ulcerative Colitis
