Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cyclic AMP and insulin release.

V Grill

    Acta Paediatrica Scandinavica. Supplement
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Cyclic adenosine monophosphate (cAMP) levels rise with glucose, stimulating insulin secretion in rat islets. This nucleotide signaling is crucial for insulin release, but other factors are also involved.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Time dynamics of elevated glucose and beta-hydroxybutyrate on beta cell mitochondrial metabolism.

    Islets·2025
    Same author

    Increased uptake of oxLDL does not exert lipotoxic effects in insulin-secreting cells.

    Journal of molecular endocrinology·2019
    Same author

    Family history of type 1 and type 2 diabetes and risk of latent autoimmune diabetes in adults (LADA).

    Diabetes & metabolism·2017
    Same author

    Autoimmune diabetes in adults and risk of myocardial infarction: the HUNT study in Norway.

    Journal of internal medicine·2016
    Same author

    Use of Swedish smokeless tobacco (snus) and the risk of Type 2 diabetes and latent autoimmune diabetes of adulthood (LADA).

    Diabetic medicine : a journal of the British Diabetic Association·2016
    Same author

    Fructosamine is a risk factor for myocardial infarction and all-cause mortality - Longitudinal experience from the AMORIS cohort.

    Nutrition, metabolism, and cardiovascular diseases : NMCD·2015
    Same journal

    Gonadotrophin-releasing hormone analogues as therapeutic probes in human growth and development: evidence from children with central precocious puberty.

    Acta paediatrica Scandinavica. Supplement·1991
    Same journal

    Growth hormone receptor deficiency (Laron syndrome): clinical and genetic characteristics.

    Acta paediatrica Scandinavica. Supplement·1991
    Same journal

    The nature of nutritional deficiency in relation to growth failure and poverty.

    Acta paediatrica Scandinavica. Supplement·1991
    Same journal

    Aspects of anthropometric evaluation of malnutrition in childhood.

    Acta paediatrica Scandinavica. Supplement·1991
    Same journal

    Breast feeding and the older infant.

    Acta paediatrica Scandinavica. Supplement·1991
    Same journal

    Can maternal dietary supplements help in preventing infant malnutrition?

    Acta paediatrica Scandinavica. Supplement·1991
    See all related articles

    Area of Science:

    • Endocrinology
    • Cellular Biology
    • Metabolic Research

    Background:

    • Insulin secretion is vital for glucose homeostasis.
    • The role of cyclic adenosine-3',5'-monophosphate (cAMP) in this process requires further elucidation.
    • Previous studies suggest a link between glucose metabolism and intracellular signaling pathways.

    Purpose of the Study:

    • To investigate the precise role of cAMP in glucose-stimulated insulin secretion.
    • To determine the relationship between glucose concentrations and cAMP levels in pancreatic beta-cells.
    • To explore the influence of various compounds on both cAMP and insulin release.

    Main Methods:

    • Experiments conducted on isolated rat islets of Langerhans.
    • Measurement of insulin secretion in response to varying glucose concentrations.

    Related Experiment Videos

  • Quantification of intracellular cAMP levels under different stimulation conditions.
  • Assessment of the effects of glucose isomers, epimers, sulfonylureas, methyl xanthines, and cholera toxin.

    • Main Results:

    • Glucose administration increased both cAMP levels and insulin secretion in parallel in rat islets.
    • Similar glucose concentrations elicited both cAMP and insulin responses.
    • Sulfonylurea compounds also influenced cAMP and insulin secretion similarly.
    • However, potentiation of glucose-induced insulin secretion occurred without significant cAMP changes.
    • Elevated cAMP by non-glucose agents did not invariably lead to insulin release.
    • Impaired cAMP response observed in fasting, neonatal states, and diabetes mellitus.

    Conclusions:

    • cAMP metabolism in beta-cells is closely linked to glucose and sulfonylurea actions on insulin secretion.
    • Additional glucose-influenced factors are necessary for optimal insulin release.
    • The cAMP pathway plays a significant role in physiological and pathophysiological conditions associated with reduced insulin secretion.