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Updated: Jun 6, 2026
10:04
Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
Published on: August 1, 2025
Dendritic cells and T cells in immunotherapy.
1NYU School of Medicine, NYU Cancer Institute, Vaccine and Cell Therapy Core Laboratory, New York, NY 10011, USA. oneilld8@gmail.com
Journal of Drugs in Dermatology : JDD
|November 11, 2010
Summary
Autologous cellular immunotherapies, including active immunization and adoptive T-cell therapies, are emerging treatments for cancer. The FDA approval of sipuleucel-T marks a significant step for active immunization in treating established cancer.
Area of Science:
- Immunology
- Oncology
- Biotechnology
Background:
- Autologous cellular immunotherapies represent a promising frontier in cancer treatment.
- These therapies leverage the patient's own immune system to combat cancer.
- Two main categories exist: active cellular immunotherapies and adoptive T-cell therapies.
Purpose of the Study:
- To review the landscape of autologous cellular immunotherapies for cancer treatment.
- To highlight the significance of recent advancements and approvals in the field.
Main Methods:
- Review of experimental and approved autologous cellular immunotherapy approaches.
- Categorization of therapies based on immune cell type and ex vivo manipulation.
Main Results:
- Autologous cellular immunotherapies are being investigated for various cancers.
- Active immunotherapies utilize dendritic cells or antigen-presenting cells.
- Adoptive T-cell therapies involve ex vivo expansion of T lymphocytes.
Conclusions:
- The FDA approval of sipuleucel-T for prostate cancer validates active immunization strategies.
- Active immunization is now an established approach for treating existing cancer.
- Cellular immunotherapies hold significant potential for future cancer therapeutics.
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