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Dendritic cells and T cells in immunotherapy

David W O'Neill1

  • 1NYU School of Medicine, NYU Cancer Institute, Vaccine and Cell Therapy Core Laboratory, New York, NY 10011, USA. oneilld8@gmail.com

Journal of Drugs in Dermatology : JDD
|November 11, 2010
PubMed

Autologous cellular immunotherapies have been used experimentally in humans to treat many types of cancer. These therapies are divided into two principal types: active cellular immunotherapies that rely on autologous dendritic cells or other antigen presenting cells; and adoptive T-cell therapies, in which large numbers of antigen-specific T lymphocytes are propagated ex vivo and then infused back into the patient. With the FDA approval of the antigen presenting cell vaccine sipuleucel-T for prostate cancer, active immunization has become an accepted approach for the treatment of established cancer.

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