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Updated: Jun 6, 2026

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases
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Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases

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Changes in rosacea comorbidities and treatment utilization over time.

Brad A Yentzer1, Alan B Fleischer

  • 1Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1071, USA.

Journal of Drugs in Dermatology : JDD
|November 11, 2010
PubMed
Summary

Physicians are shifting rosacea treatment away from systemic antibiotics due to resistance concerns. Azelaic acid prescriptions are increasing, while dermatologists reduce systemic medication use for this chronic skin condition.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Epidemiology

Background:

  • Rosacea is a chronic skin condition necessitating long-term management.
  • Increasing antibiotic resistance prompts re-evaluation of long-term antibiotic use for rosacea.
  • Comorbidities are frequently observed in patients diagnosed with rosacea.

Purpose of the Study:

  • To analyze trends in rosacea treatment modalities.
  • To investigate comorbidities associated with rosacea.
  • To compare prescribing patterns between dermatologists and other physicians.

Main Methods:

  • Analysis of the National Ambulatory Medical Care Survey data from 2002-2006.
  • Inclusion of drug mentions and coexisting diagnoses for rosacea-related physician visits.

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Last Updated: Jun 6, 2026

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases
07:36

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases

Published on: July 3, 2025

  • Comparative analysis of prescribing behaviors.

    • Main Results:

    • Rosacea was diagnosed in 10 million physician visits, with 74% having associated comorbidities.
    • Top prescribed medications included metronidazole, tetracyclines, azelaic acid, and sodium sulfacetamide.
    • Prescribing of azelaic acid increased, while sodium sulfacetamide decreased; dermatologists reduced systemic medication prescriptions.

    Conclusions:

    • Dermatologists are decreasing their reliance on systemic antibiotics for rosacea treatment.
    • Therapies like azelaic acid, which do not promote bacterial resistance, are increasingly favored.
    • This shift reflects a move towards safer, long-term rosacea management strategies.