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Group A variants defined with a monoclonal anti-A reagent
Transfusion
|February 1, 1990
Summary
Two blood donors showed unusual B(A) serologic findings mimicking the B(A) phenomenon. Further studies confirmed aberrant group A activities, suggesting further investigation for atypical B(A) phenotypes to delineate ABO blood groups.
Area of Science:
- Blood group serology
- Immunogenetics
- Transfusion medicine
Background:
- The ABO blood group system is crucial for safe blood transfusions.
- Aberrant antigen expression can lead to transfusion complications.
- The B(A) phenomenon is a rare serologic finding.
Purpose of the Study:
- To investigate unusual serologic findings in two group B blood donors.
- To confirm the presence of aberrant group A activities.
- To understand the implications for ABO blood group delineation.
Main Methods:
- Utilized blended murine monoclonal anti-A reagent for initial testing.
- Performed binding experiments using affinity chromatography for confirmation.
- Conducted detailed serologic investigations.
Main Results:
- Observed serologic findings mimicking the B(A) phenomenon in two group B donors.
- Confirmed the presence of aberrant group A activities through additional studies.
- Demonstrated the utility of affinity chromatography in characterizing atypical blood group activities.
Conclusions:
- Atypical B(A) phenotypes can present with unusual serologic patterns.
- Further investigation is warranted for individuals with atypical B(A) phenotypes.
- Accurate ABO blood group delineation is essential for transfusion safety.