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Related Concept Videos

Peritoneal Dialysis I: Introduction and Procedure01:30

Peritoneal Dialysis I: Introduction and Procedure

Peritoneal dialysis (PD) is a procedure that facilitates the exchange of solutes, waste products, electrolytes, and excess fluid between the blood in the peritoneal capillaries and a dialysis solution introduced into the peritoneal cavity.Principles of Peritoneal Dialysis (PD)Diffusion: Waste products such as urea and electrolytes move from high concentrations in the blood to low concentrations in the dialysate across the peritoneal membrane. This mechanism is driven by the concentration...
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
Peritoneal Dialysis III: Nursing Management01:25

Peritoneal Dialysis III: Nursing Management

Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
Peritoneum01:21

Peritoneum

The peritoneum is a vital membrane that lines the abdominal cavity and covers most of the organs within it. It plays a crucial role in protecting the organs, providing a smooth surface for their movement, and facilitating various physiological processes. Understanding the anatomy and function of the peritoneum is essential for comprehending the complexities of the abdominal region.
Anatomy of the Peritoneum
The peritoneum is divided into two layers: the parietal peritoneum and the visceral...

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Related Experiment Video

Updated: Jun 6, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

Intraperitoneal therapy for peritoneal cancer.

Ze Lu1, Jie Wang, M Guillaume Wientjes

  • 1Optimum Therapeutics, LLC, Columbus, OH, USA.

Future Oncology (London, England)
|November 11, 2010
PubMed
Summary

Intraperitoneal therapy offers survival benefits for peritoneal cancers but faces challenges. This research explores novel drug-loaded microparticles to improve tumor penetration and reduce toxicity for better cancer treatment.

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Last Updated: Jun 6, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
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Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

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Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

Area of Science:

  • Oncology
  • Nanomedicine
  • Drug Delivery

Background:

  • Peritoneal cancers (ovarian, pancreatic, colorectal, gastric, liver) cause ~250,000 US cases annually.
  • Peritoneal metastases are common, necessitating effective locoregional treatments.
  • Intraperitoneal therapy shows promise but is limited by toxicity and poor tumor penetration.

Purpose of the Study:

  • To review peritoneal metastasis and intraperitoneal therapy.
  • To discuss pharmacokinetic challenges in intraperitoneal drug delivery.
  • To introduce novel drug-loaded tumor-penetrating microparticles.

Main Methods:

  • Literature review of peritoneal metastasis and intraperitoneal therapy.
  • Analysis of pharmacokinetic principles for intraperitoneal drug delivery.
  • Development and characterization of drug-loaded microparticles designed for tumor penetration.

Main Results:

  • Intraperitoneal therapy has demonstrated survival benefits, particularly in ovarian cancer.
  • Current limitations include toxicity and inadequate penetration of bulky tumors (>1 cm).
  • Novel microparticle formulation shows potential for enhanced tumor penetration.

Conclusions:

  • Overcoming limitations of current intraperitoneal therapy is crucial for improved patient outcomes.
  • Drug-loaded tumor-penetrating microparticles represent a promising approach.
  • Further research is needed to translate this technology into clinical practice.