Related Experiment Video

Updated: Jun 6, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Pediatric thrombosis

Alenka Trampus-Bakija1

  • 1University Children's Hospital, University Medical Centre, Ljubljana, Slovenia. alenka.trampus@guest.arnes.si

Clinical Chemistry and Laboratory Medicine
|November 11, 2010
PubMed

Insights

Pediatric thrombosis is rare and often linked to underlying conditions like central venous catheters. Understanding developmental hemostasis is crucial for diagnosing and managing thrombotic disorders in children.

Area of Science:

  • Pediatric Hematology
  • Thrombosis and Hemostasis

Background:

  • Thrombosis in children is increasingly recognized, with true idiopathic cases being rare.
  • Central venous catheterization is the primary risk factor for thrombosis in pediatric patients.
  • Children often present with genetic abnormalities or coagulation deficiencies contributing to thrombotic risk.

Purpose of the Study:

  • To review the complexities of thrombotic states in children.
  • To emphasize the significance of developmental hemostasis in pediatric thrombosis.
  • To guide the selection and interpretation of diagnostic tests for thrombotic disorders.

Main Methods:

  • Literature review focusing on pediatric thrombosis.
  • Discussion of diagnostic challenges and genetic factors.
  • Analysis of anticoagulant monitoring strategies.

Main Results:

  • Pediatric thrombosis is heterogeneous and influenced by developmental hemostasis.
  • Central venous catheters are a major risk factor.
  • Genetic abnormalities are more prevalent in children with thrombosis than adults.

Conclusions:

  • Accurate diagnosis requires understanding developmental hemostasis and genetic factors.
  • Appropriate test selection and interpretation are vital for managing pediatric thrombosis.
  • Effective monitoring of anticoagulant therapy is essential for patient outcomes.

More Related Videos

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock09:09

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

Published on: November 3, 2023

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...