Related Experiment Video
Updated: Jun 6, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
Published on: April 13, 2015
The human and canine TERT promoters function equivalently in human and canine cells
M L Arendt1, L Nasir, I M Morgan
1Institute of Comparative Medicine, University of Glasgow, Glasgow, UK. maja_a@life.ku.dk
Abstract:
Telomerase targeted cancer gene therapy is being exploited for treatment of human cancer. The high incidence and many comparative aspects of human and canine cancer and the compliance and dedication of dog owners to treat cancer makes the canine pet population a good clinical model for investigating and developing new cancer therapeutics. Here, we report that the human telomerase promoter operates in canine cells, suggesting that human telomerase promoter-driven cancer therapy can be used to treat cancer in canines. Therefore, the canine pet population can act as a clinical model for new drug development based on telomerase therapeutics.
More Related Videos
Related Concept Videos
The Eukaryotic Promoter Region
General Transcription Factors
Telomeres and Telomerase
Transcription Factors
The Central Dogma
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
The Central Dogma

