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The altered expression of ING5 protein is involved in gastric carcinogenesis and subsequent progression

Ya-nan Xing1, Xue Yang, Xiao-yan Xu

  • 1Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang 110001, China.

Human Pathology
|November 11, 2010
PubMed

Insights

Investigating ING5 in gastric cancer revealed aberrant expression. Lower nuclear ING5 correlates with poor prognosis, suggesting ING5 as a potential marker for gastric carcinoma aggressiveness.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pathology

Background:

  • ING5 interacts with p53, influencing cell growth and apoptosis.
  • The role of ING5 in gastric tumorigenesis and progression requires clarification.

Purpose of the Study:

  • To investigate the expression patterns of ING5 in gastric nonneoplastic mucosa, dysplasia, and carcinomas.
  • To correlate ING5 expression with clinicopathologic parameters and patient prognosis in gastric carcinoma.

Main Methods:

  • Immunohistochemistry on tissue microarrays.
  • Western blot and RT-PCR analysis of gastric carcinoma tissues and cell lines.

Main Results:

  • ING5 mRNA expression increased in gastric carcinoma versus paired mucosa.
  • Lower nuclear ING5 and higher cytoplasmic ING5 expression were observed in dysplasia and carcinoma compared to nonneoplastic mucosa.
  • Nuclear ING5 negatively correlated with tumor size, invasion, metastasis, and stage, while cytoplasmic ING5 showed positive associations.
  • Nuclear ING5 expression was linked to favorable prognosis in gastric carcinoma patients.

Conclusions:

  • Aberrant ING5 expression is implicated in the pathogenesis, growth, and invasion of gastric carcinomas.
  • ING5 may serve as a prognostic marker for gastric carcinoma aggressiveness and patient outcomes.

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