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Related Concept Videos

Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
IP3/DAG Signaling Pathway01:11

IP3/DAG Signaling Pathway

Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and produces two-second...
GPCR Desensitization01:12

GPCR Desensitization

G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
Cloning of Dolly the Sheep01:08

Cloning of Dolly the Sheep

The first successfully cloned mammal was Dolly, a sheep, born on 5th July 1996 at Roslin Institute, Scotland. The cloned sheep was named after the American singer Dolly Parton. Dolly lived for seven years and died of respiratory complications, which is speculated to be due to the actual age of her DNA. Because the DNA in cloned cells belongs to an older individual,  the cloned individual’s life expectancy may be affected. Indeed, analysis of Dolly’s DNA revealed shorter telomeres than other...
cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
Receptor Tyrosine Kinases01:26

Receptor Tyrosine Kinases

Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...

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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

UKPMC: a full text article resource for the life sciences.

Johanna R McEntyre1, Sophia Ananiadou, Stephen Andrews

  • 1EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. mcentyre@ebi.ac.uk

Nucleic Acids Research
|November 11, 2010
PubMed
Summary
This summary is machine-generated.

UK PubMed Central (UKPMC) enhances the PubMed Central (PMC) repository, offering integrated searching and advanced features for open-access biomedical literature. It provides tools for manuscript deposit, grant linking, and citation tracking.

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A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
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Last Updated: Jun 6, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

Area of Science:

  • Biomedical Informatics
  • Scientific Literature Databases
  • Open Access Publishing

Background:

  • UK PubMed Central (UKPMC) was established as the first mirror site to PubMed Central (PMC).
  • The project aimed to ensure international preservation of open-access biomedical literature.
  • UKPMC has evolved significantly since its 2007 launch, expanding its functionalities beyond the original PMC repository.

Purpose of the Study:

  • To describe the UKPMC database and its functionalities.
  • To clarify the relationship between PubMed Central (PMC) and UK PubMed Central (UKPMC).
  • To provide historical context and outline future directions for UKPMC.

Main Methods:

  • Integrated searching of full-text articles and abstracts from UKPMC and PubMed.
  • Inclusion of diverse records such as Agricola, Patents, and biomedical theses.
  • Implementation of text-mining for content enrichment and integration with related databases.

Main Results:

  • UKPMC offers a unified search interface for comprehensive literature discovery.
  • Advanced features include 'Cited By' information for literature navigation.
  • UKPMC+ services facilitate manuscript deposition, grant linkage, and citation tracking for researchers.

Conclusions:

  • UKPMC serves as a vital, evolving resource for accessing and managing biomedical literature.
  • Its integrated approach and added-value services enhance research discoverability and workflow.
  • The database plays a crucial role in the preservation and dissemination of open-access scientific publications.