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Glial Cells01:04

Glial Cells

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The Essentials of a Global Index for Cognitive Function.

Translational neuroscience·2017
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Culturing Microglia from the Neonatal and Adult Central Nervous System
11:28

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Published on: August 9, 2013

Grooming and growing with microglia.

Joseph Mathew Antony1

  • 1Department of Medical Biophysics, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5. joseph.antony@utoronto.ca

Science Signaling
|November 11, 2010
PubMed
Summary
This summary is machine-generated.

Microglia, the brain's immune cells, are now linked to behavior. A new study shows that Hoxb8-expressing microglia play a role in modulating how we act, opening new research avenues.

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Last Updated: Jun 6, 2026

Culturing Microglia from the Neonatal and Adult Central Nervous System
11:28

Culturing Microglia from the Neonatal and Adult Central Nervous System

Published on: August 9, 2013

Isolation and Culture of Rodent Microglia to Promote a Dynamic Ramified Morphology in Serum-free Medium
12:00

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09:12

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Area of Science:

  • Neuroscience
  • Immunology
  • Developmental Biology

Background:

  • Microglia are key immune cells in the central nervous system.
  • They are known to mediate both neuroprotection and neuropathogenesis.
  • Their direct role in behavior has not been previously established.

Purpose of the Study:

  • To investigate the role of microglia in behavior.
  • To explore the specific contribution of Hoxb8-expressing microglia to behavioral modulation.

Main Methods:

  • The study likely involved genetic manipulation or specific targeting of Hoxb8-expressing microglia in model organisms.
  • Behavioral assays were used to assess the impact of microglial manipulation on actions.

Main Results:

  • A direct association between microglia and behavior was demonstrated.
  • Hoxb8-expressing microglia were found to modulate specific behaviors.

Conclusions:

  • Microglia are implicated as significant players in the regulation of behavior.
  • This finding bridges the fields of neuroimmunology, pathology, and developmental biology.