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Syzygium cumini extract decrease adenosine deaminase, 5'nucleotidase activities and oxidative damage in platelets of
Karine S De Bona1, Luziane P Bellé, Marcel H Sari
1Postgraduate Program in Pharmaceutical Sciences, Health Science Centre, Federal University of Santa Maria (UFSM), Santa Maria, Brazil.
Summary
Syzygium cumini aqueous extract (ASc) shows potential in managing diabetes complications. It reduces oxidative stress and modulates adenosine levels in patients with Type 2 diabetes mellitus, improving platelet function.
Area of Science:
- Biochemistry
- Pharmacology
- Metabolic Disorders
Background:
- Diabetes mellitus is a chronic metabolic disorder with escalating prevalence and severe long-term complications.
- Hyperglycemia in diabetes exacerbates oxidative stress by disrupting the oxidant/antioxidant balance.
- Syzygium cumini has a long history of traditional use in managing diabetes.
Purpose of the Study:
- To investigate the in vitro effects of Syzygium cumini aqueous leaves extract (ASc) on adenosine deaminase (ADA) and 5'-Nucleotidase (5'NT) activities.
- To evaluate the impact of ASc on oxidative stress markers in platelets from Type 2 diabetes mellitus patients.
- To explore ASc's role in modulating adenosine levels and platelet function in diabetic conditions.
Main Methods:
- Utilized platelet-rich plasma (PRP) from Type 2 diabetes mellitus patients for in vitro assays.
- Assayed activities of Adenosine deaminase (ADA), 5'-Nucleotidase (5'NT), Catalase (CAT), and Superoxide Dismutase (SOD).
- Quantified Thiobarbituric acid reactive substances (TBARS) as a marker of lipid peroxidation.
Main Results:
- Elevated ADA, 5'NT activities, and TBARS levels were observed in diabetic platelets compared to controls.
- ASc treatment (100 and 200 μg/mL) significantly inhibited the increased ADA, 5'NT activities, and TBARS levels.
- ASc demonstrated antioxidant properties by scavenging oxidant species and modulating adenosine levels.
Conclusions:
- Syzygium cumini aqueous extract (ASc) exhibits antioxidant effects relevant to diabetes.
- ASc normalizes elevated ADA and 5'NT activities and reduces oxidative stress in diabetic platelets.
- ASc may offer a therapeutic benefit by improving platelet function and counteracting diabetes-induced oxidative damage.
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