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Lipid profile in Jordanian patients with first ever ischemic stroke

Said S Dahbour1

  • 1Department of Neurology, Faculty of Medicine, Jordan University, PO Box 23076, Amman 11115, Jordan.

Neurosciences (Riyadh, Saudi Arabia)
|November 11, 2010
PubMed

Insights

This study found that patients experiencing their first ischemic stroke (IS) had significantly lower high-density lipoprotein (HDL) levels compared to controls. Other lipid profiles like total cholesterol, LDL, and triglycerides did not show significant differences.

Area of Science:

  • Cardiovascular Medicine
  • Neuroscience
  • Clinical Biochemistry

Background:

  • Ischemic stroke (IS) is a leading cause of disability and mortality worldwide.
  • Lipid profiles, including total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TG), are established risk factors for cardiovascular diseases.
  • Understanding the specific lipid profile alterations in IS patients is crucial for risk stratification and targeted interventions.

Purpose of the Study:

  • To investigate the association between lipid profiles (TC, LDL, HDL, TG) and first-ever ischemic stroke (IS) in Jordanian patients.
  • To compare the lipid profiles of IS patients with a control group admitted to a teaching hospital.
  • To identify potential lipid-related biomarkers for ischemic stroke in this population.

Main Methods:

  • A retrospective case-control study was conducted involving IS patients and controls admitted to Jordan University Hospital between January 2004 and December 2006.
  • Fasting lipid profiles were analyzed within 48 hours of admission for all participants.
  • Demographic data and prevalence of risk factors such as hypertension, diabetes mellitus, and ischemic heart disease (IHD) were compared between groups.

Main Results:

  • The study included 98 IS patients and 98 controls, with no significant differences in age, gender, hypertension, diabetes, IHD, or smoking prevalence.
  • IS patients exhibited significantly lower high-density lipoprotein (HDL) levels compared to the control group (p-value not specified).
  • No significant differences were observed in total cholesterol (TC), low-density lipoprotein (LDL), or triglycerides (TG) between the IS patients and controls. The control group had higher statin usage.

Conclusions:

  • The findings suggest a significant association between lower high-density lipoprotein (HDL) levels and ischemic stroke (IS) in the studied Jordanian population.
  • Despite limitations of the retrospective design, the results highlight HDL as a potential indicator in IS.
  • Further prospective studies are warranted to confirm these findings and elucidate the role of HDL in IS pathogenesis.
Abstract

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