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Loss of Tumor Suppressor Gene Functions

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...

Loss of Tumor Suppressor Gene Functions

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

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Related Experiment Video

Updated: Jun 6, 2026

In vitro Organoid Culture of Primary Mouse Colon Tumors

In vitro Organoid Culture of Primary Mouse Colon Tumors

Published on: May 17, 2013

Rab25 as a tumour suppressor in colon carcinogenesis.

J R Goldenring¹, K T Nam

¹Nashville VA Medical Center and the Department of Surgery, Epithelial Biology Center, Vanderbilt University School of Medicine, 10435G MRBIV, 2213 Garland Avenue, Nashville, TN 37232-2733, USA. jim.goldenring@vanderbilt.edu

British Journal of Cancer

|November 11, 2010

Summary

Rab25, a protein involved in cell transport, acts as a tumor suppressor in the colon. Its deficiency promotes colon cancer development, suggesting a crucial role in maintaining intestinal health.

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Area of Science:

Cell biology
Molecular oncology
Gastrointestinal pathology

Background:

Intracellular vesicle trafficking is crucial for epithelial cell function.
Rab25, a small GTPase, is implicated in epithelial cancers.
Rab25 expression patterns vary across different cancer types, with decreased levels in colon cancer.

Purpose of the Study:

To investigate the role of Rab25 in colonic neoplasia.
To understand the impact of Rab25 deficiency on tumor development.
To explore the mechanisms underlying Rab25's function in the colon.

Main Methods:

Analysis of Rab25 expression in human colon cancer.
Studies using mouse models of intestinal and colonic neoplasia.
Investigation of β1-integrin trafficking in relation to Rab25 function.

Main Results:

Rab25 deficiency significantly promotes the development of colonic neoplasia in mouse models.
Altered β1-integrin trafficking to the cell surface is associated with Rab25 deficiency.
Rab25 expression is decreased in human colon cancers, irrespective of stage.

Conclusions:

Rab25 functions as a tumor suppressor in the context of colonic neoplasia.
Rab25 plays a critical role in regulating intestinal epithelial homeostasis.
Targeting Rab25 pathways may offer therapeutic strategies for colon cancer.