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Inflammatory bowel disease in India--changing paradigms
1Gastroenterology Unit, Department of Medicine, B.R. Singh Hospital and Centre for Medical Education and Research, Eastern Railway, Sealdah, Kolkata 700014 West Bengal, India. gautam1910@yahoo.com
International Journal of Colorectal Disease
|November 11, 2010
Summary
Inflammatory bowel disease is increasing in India, with ulcerative colitis now presenting more severely. Crohn's disease in this region often involves the small intestine and responds well to aminosalicylates.
Area of Science:
- Gastroenterology
- Internal Medicine
- Epidemiology
Background:
- Inflammatory bowel disease (IBD) is a growing health concern in Asia, particularly India.
- Limited clinical data and temporal trend information exist for IBD in eastern India.
Purpose of the Study:
- To analyze the clinical characteristics and temporal trends of inflammatory bowel disease in eastern India.
- To compare current IBD patient data with historical data to identify significant changes.
Main Methods:
- Retrieved existing Indian IBD data from PubMed.
- Collected prospective clinical data from 50 IBD patients (40 ulcerative colitis, 10 Crohn's disease) from 2003-2009.
- Analyzed demography, symptoms, disease course, complications, and treatment outcomes using descriptive and analytical statistics.
Main Results:
- Ulcerative colitis patients presented with severe pancolitis, contrasting with milder earlier presentations.
- 27.5% of ulcerative colitis patients developed pseudopolyposis, and 10% developed colon cancer with disease duration >10 years.
- Crohn's disease patients typically had mild small-gut involvement, responsive to aminosalicylates; lower GI bleed was a common presentation.
Conclusions:
- Ulcerative colitis in India is increasingly presenting with greater severity and extent.
- Rapid development of colonic pseudopolyposis is a notable observation in ulcerative colitis patients.
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