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The relationship between spinal trabecular bone mineral content and iliac crest trabecular bone volume
C D Wright1, E O Crawley, W D Evans
1Department of Pathology, University of Wales College of Medicine, Cardiff, United Kingdom.
Calcified Tissue International
|March 1, 1990
Summary
Spinal bone density and hip bone volume correlate in osteoporosis patients. However, this relationship varies significantly based on the osteoporosis cause, suggesting different bone loss patterns.
Area of Science:
- Orthopedics
- Rheumatology
- Endocrinology
Background:
- Osteoporosis is a skeletal disorder characterized by compromised bone strength.
- Trabecular bone is crucial for bone strength and is affected in osteoporosis.
- Assessing the relationship between spinal and iliac crest bone properties is important for understanding osteoporosis.
Purpose of the Study:
- To investigate the correlation between spinal trabecular bone mineral density and iliac crest trabecular bone volume.
- To determine if this correlation differs across various osteoporosis etiologies.
Main Methods:
- Quantitative computed tomography (QCT) measured spinal bone mineral density in lumbar vertebrae.
- Histomorphometry assessed iliac crest bone volume from trans-iliac biopsies.
- Data analyzed for 84 patients, including primary osteoporosis, secondary osteoporosis (inflammatory bowel disease), and rheumatoid arthritis.
Main Results:
- A significant positive correlation (r=0.60) was observed between spinal bone mineral density and iliac crest bone volume in all patients.
- This correlation was significant in secondary osteoporosis (r=0.65) but not in primary osteoporosis (r=0.07) or rheumatoid arthritis (r=0.19).
Conclusions:
- The relationship between spinal and iliac crest trabecular bone parameters is disease-dependent.
- These findings suggest distinct skeletal patterns of bone loss in different types of osteoporosis.