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Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting

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Antiemetic research: future directions.

Ian Olver¹, Alexander Molassiotis, Matti Aapro

¹Cancer Council Australia, Sydney 2000, Australia. ian.olver@cancer.org.au

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer

|November 11, 2010

Summary

Future research should focus on predicting nausea and vomiting using patient factors and genetics. New trials need standardized stimuli, optimal dosing, and assessment of side effects and quality of life, with nausea as a key endpoint.

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Area of Science:

Oncology
Pharmacology

Background:

The Multinational Association of Supportive Care in Cancer (MASCC) antiemetic guidelines were reviewed in 2009.
An expert group identified key areas for future antiemetic research.

Purpose of the Study:

To outline directions for future research in antiemetics based on a review of existing guidelines.
To identify gaps in current knowledge and suggest methodologies for improving antiemetic therapy.

Main Methods:

Expert group review of existing MASCC antiemetic guidelines.
Identification of research priorities based on current limitations and future needs in antiemetic therapy.

Main Results:

Future research should integrate patient prognostic factors, genetic identification of receptors, and pharmacogenetic studies.
Trial design needs standardization of emetic stimuli, determination of optimal antiemetic doses and schedules, and assessment of delayed emesis control.
New primary endpoints, such as nausea, and economic endpoints should be incorporated into trials.
Research is needed on novel antiemetic drug targets, corticosteroid use, and the emetic potential of new chemotherapy regimens and targeted therapies.
Further studies are required in specific populations like those receiving high-dose chemotherapy, radiation therapy, or in children.

Conclusions:

Improving the prediction and management of chemotherapy-induced nausea and vomiting requires a multi-faceted approach.
Future research should address complex symptoms like nausea, cost-effectiveness, and specific patient populations.
Advances in understanding receptor targets and drug metabolism will inform the development of more effective antiemetic strategies.