Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
Genital Herpes01:23

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Rabies01:28

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A rare case of multisystem autoimmune disease presenting with retinopathy and alopecia post COVID-19 vaccination.

Journal of ophthalmic inflammation and infection·2026
Same author

Critical appraisal of intravitreal triamcinolone acetonide for serpiginous-like choroiditis in a tuberculosis-endemic setting.

Indian journal of ophthalmology·2026
Same author

Protective Role of Metformin in Glaucoma: Prospective Cohort Study, Meta-Analysis, and Drug-Target Mendelian Randomization.

Ophthalmology science·2026
Same author

Physiological change in ganglion cell inner plexiform layer and nerve fibre layer thickness over six years.

Clinical & experimental ophthalmology·2025
Same author

Artificial Intelligence in Uveitis: Innovations in Diagnosis and Therapeutic Strategies.

Clinical ophthalmology (Auckland, N.Z.)·2024
Same author

Deep learning-based normative database of anterior chamber dimensions for angle closure assessment: the Singapore Chinese Eye Study.

The British journal of ophthalmology·2024

Related Experiment Video

Updated: Jun 6, 2026

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
08:31

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals

Published on: September 20, 2021

Herpes zoster ophthalmicus.

Srinivasan Sanjay1, Philemon Huang, Raghavan Lavanya

  • 1Ophthalmology and Visual Sciences, Khoo Teck Puat Hospital, Alexandra Health, 90 Yishun Central, Singapore, 768828, Singapore, sanjay_s@alexandrahealth.sg.

Current Treatment Options in Neurology
|November 11, 2010
PubMed
Summary
This summary is machine-generated.

Herpes zoster ophthalmicus (HZO) management requires a multidisciplinary approach to prevent sight-threatening ocular complications. Prompt treatment with antivirals and supportive care is crucial for reducing morbidity and chronic pain.

More Related Videos

Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection
07:55

Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection

Published on: November 3, 2012

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
07:27

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

Related Experiment Videos

Last Updated: Jun 6, 2026

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
08:31

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals

Published on: September 20, 2021

Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection
07:55

Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection

Published on: November 3, 2012

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
07:27

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Virology

Background:

  • Herpes zoster ophthalmicus (HZO) is a reactivation of the varicella-zoster virus affecting the ophthalmic nerve.
  • HZO can lead to severe ocular complications, including keratitis, uveitis, and cranial nerve palsies, potentially causing significant visual disability.
  • Pain, particularly postherpetic neuralgia (PHN), is a predominant and debilitating symptom in HZO patients.

Purpose of the Study:

  • To outline the multidisciplinary management of HZO, focusing on the prevention and treatment of ocular complications.
  • To describe the acute and chronic ocular manifestations of HZO.
  • To discuss the management of pain and other postherpetic complications.

Main Methods:

  • Review of clinical practice for managing HZO patients.
  • Evaluation of acute and chronic ocular complications.
  • Recommendation of treatment strategies including oral and topical antivirals, steroids, lubricants, and pain management modalities.
  • Consideration of surgical interventions after stabilization of ocular inflammation.

Main Results:

  • Acute complications include epithelial, stromal, and disciform keratitis; anterior uveitis; necrotizing retinitis; and cranial nerve palsies.
  • Chronic complications encompass neurotrophic keratitis, mucus plaque keratitis, and lipid degeneration.
  • Postherpetic neuralgia (PHN) affects over half of HZO patients, characterized by severe, chronic pain managed with local and systemic treatments.
  • Cranial nerve palsies, especially facial nerve involvement, are common, with potential for complete ophthalmoplegia, though recovery is often complete.

Conclusions:

  • Effective HZO management necessitates a comprehensive approach addressing both ocular and systemic manifestations.
  • Early detection and treatment with acyclovir and supportive therapies are vital for preventing vision loss.
  • Management of chronic pain and complications like PHN requires a coordinated effort between ophthalmologists and other medical specialists.
  • Vaccination against varicella-zoster virus is recommended for at-risk individuals to prevent HZ and its complications.