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Tissue-type plasminogen activator: intracoronary applications
1Cardiovascular Division, Washington University School of Medicine, St. Louis, MO 63110.
Insights
Intracoronary tissue-type plasminogen activator (t-PA) effectively treated evolving myocardial infarction in four patients, either before, after, or instead of angioplasty. This study explores intracoronary thrombolysis roles and safety for heart attack patients.
Area of Science:
- Cardiology
- Interventional Cardiology
- Thrombolytic Therapy
Background:
- Myocardial infarction (MI) remains a leading cause of mortality.
- Timely reperfusion is critical for preserving myocardial function.
- Coronary artery angioplasty is a primary reperfusion strategy, but alternatives are needed.
Abstract:
Intracoronary tissue-type plasminogen activator (t-PA) was employed successfully before, after, or in place of coronary artery angioplasty in four patients referred for emergency cardiac catheterization during evolving myocardial infarction. The potential roles of intracoronary thrombolysis, dose considerations for intracoronary t-PA, factors influencing the choice of plasminogen activator, and safety issues are discussed.