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Related Experiment Video

Updated: Jun 6, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Multiple myeloma and pregnancy.

Agustin Avilés¹, Natividad Neri

¹Oncology Research Unit, Oncology Hospital, National Medical Center, IMSS, 06725 México DF, Mexico. agustin.aviles@imss.gob.mx

American Journal of Hematology

|November 11, 2010

Summary

Pregnancy in multiple myeloma patients is rare. This study reports 6 new cases where mothers received chemotherapy during pregnancy, with newborns showing no malformations and no late complications observed in children over 3 years old.

Area of Science:

Hematology
Oncology
Reproductive Medicine

Background:

Pregnancy in patients with hematological malignancies is documented.
Pregnancy in multiple myeloma (MM) patients is exceptionally rare, with only 12 prior cases reported.
This study expands the literature on pregnancy in MM.

Purpose of the Study:

To report on 6 additional cases of pregnancy in multiple myeloma patients.
To describe the outcomes of chemotherapy administered during pregnancy in these patients.
To assess fetal and long-term child outcomes following in-utero exposure to MM treatment.

Main Methods:

Case series reporting on 6 pregnancies in women with multiple myeloma.
Details of chemotherapy regimens, including those in the first trimester, are provided.

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Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

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Newborn assessment for malformations and long-term follow-up of children were conducted.

Main Results:

Six pregnancies in multiple myeloma patients were identified.
All newborns (3 male, 3 female) had birth weights >2500g and no fetal malformations.
No late complications were observed in children during follow-up periods exceeding 3 years.
Three mothers underwent stem cell transplantation.

Conclusions:

Pregnancy is possible in multiple myeloma patients, even with chemotherapy.
Chemotherapy during pregnancy, including the first trimester, did not result in fetal malformations in this cohort.
Long-term outcomes for children born to mothers with multiple myeloma treated during pregnancy appear favorable.