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Related Concept Videos

Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Related Experiment Video

Updated: Jun 6, 2026

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
09:10

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

Radiation bowel disease and its clinical implication.

E N Salmo1, N Y Haboubi

  • 1Department of Histopathology, Royal Bolton Hospital, United Kingdom.

Acta Chirurgica Iugoslavica
|November 12, 2010
PubMed
Summary
This summary is machine-generated.

Pre-operative radiotherapy can cause radiation colitis and tumor regression. Histological grading of radiation colitis and tumor regression is crucial for assessing disease progression and prognosis, but severity does not correlate with post-operative complications.

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Pre-operative radiotherapy is used to treat tumors, potentially causing radiation colitis and tumor regression.
  • Accurate histological evaluation of radiation colitis is necessary for disease assessment.

Purpose of the Study:

  • To establish reproducible histological grading for radiation colitis.
  • To investigate the relationship between histological features of radiation colitis and post-operative complications.
  • To assess the prognostic importance of histological grading for tumor regression.

Main Methods:

  • Histological examination of radiation colitis.
  • Grading of radiation colitis severity based on histological features.
  • Correlation analysis between histological findings and post-operative complications.
  • Histological grading of tumor regression.

Main Results:

  • Radiation colitis severity can be graded histologically.
  • Increased severity correlates with cellular atypia and reduced eosinophilic infiltrate.
  • Histological changes in radiation colitis do not appear linked to post-operative complications.
  • Tumor regression grading has prognostic significance.
  • Long-course radiotherapy patients show more post-operative complications, likely due to tumor regression, not radiotherapy type.

Conclusions:

  • Histological grading provides a reproducible method for assessing radiation colitis severity.
  • Tumor regression, assessed histologically, is a key prognostic factor.
  • Post-operative complications are more related to tumor regression than radiotherapy regimen.