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Related Concept Videos

Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...

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Related Experiment Video

Updated: Jun 6, 2026

Bridging the Bio-Electronic Interface with Biofabrication
16:38

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

A bioelectronic platform using a graphene-lipid bilayer interface.

Priscilla Kailian Ang1, Manu Jaiswal, Candy Haley Yi Xuan Lim

  • 1Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.

ACS Nano
|November 12, 2010
PubMed
Summary
This summary is machine-generated.

Graphene transistors detect antimicrobial peptides by sensing changes in lipid membranes. This electrical detection method relies on biomolecular doping and ionic screening effects for monitoring biorecognition events.

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Last Updated: Jun 6, 2026

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Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022

Area of Science:

  • Materials Science
  • Biophysics
  • Nanotechnology

Background:

  • Graphene's electronic properties are tunable via surface adsorption of charged lipid bilayers.
  • Electrolyte-gated biomimetic membrane-graphene transistors can monitor biorecognition events by detecting changes in membrane integrity.

Purpose of the Study:

  • To demonstrate electrical sensing of antimicrobial peptide bactericidal activity using graphene-based transistors.
  • To investigate the underlying mechanisms of graphene sensor response to antimicrobial peptides.

Main Methods:

  • Fabrication of electrolyte-gated biomimetic membrane-graphene transistors.
  • Adsorption of charged lipid bilayers onto graphene surfaces.
  • Electrical monitoring of graphene transistor response to antimicrobial peptides.

Main Results:

  • Graphene transistors successfully detected the bactericidal activity of antimicrobial peptides.
  • The sensing mechanism involves a combination of biomolecular doping and ionic screening effects.
  • Changes in membrane integrity due to peptide activity were correlated with electrical signal modulation.

Conclusions:

  • Graphene-based transistors offer a viable platform for the electrical detection of antimicrobial peptide activity.
  • The interplay of biomolecular doping and ionic screening is crucial for this sensing modality.
  • This approach enables label-free, real-time monitoring of biorecognition events impacting membrane integrity.