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Microperimetry and OCT findings in female carriers of choroideremia
Azzrah Thobani1, Anastasios Anastasakis, Gerald A Fishman
1Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago IL, USA.
Purpose:
To evaluate structural retinal changes and macular function by a combined spectral domain optical coherence tomography/scanning laser ophthalmoscope (OCT/SLO) microperimetry device in choroideremia carriers.
Methods And Materials:
Ten choroideremia carriers were included in the study. All subjects had a complete ophthalmic examination in addition to Goldmann kinetic visual fields, OCT and microperimetry testing on a commercially available Spectral Domain (SD) OCT/SLO combination system.
Results:
Microperimetry results demonstrated focal areas of threshold abnormalities in 50% of the subjects. OCT findings show subtle retinal pigment epithelium (RPE) irregularities with attenuation more pronounced outside the macular region.
Conclusions:
Long term follow up with microperimetric testing could be useful in monitoring any progressive loss of retinal function in choroideremia carriers.
