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Related Experiment Video

Updated: Jun 6, 2026

A Modified Lean and Release Technique to Emphasize Response Inhibition and Action Selection in Reactive Balance
07:19

A Modified Lean and Release Technique to Emphasize Response Inhibition and Action Selection in Reactive Balance

Published on: March 19, 2020

A balanced view of balanced solutions.

Bertrand Guidet1, Neil Soni, Giorgio Della Rocca

  • 1Inserm, Unité de Recherche en Épidémiologie Systèmes d'Information et Modélisation (U707), Paris F-75012, France. bertrand.guidet@sat.aphp.fr

Critical Care (London, England)
|November 12, 2010
PubMed
Summary
This summary is machine-generated.

This review examines fluid therapy, comparing balanced solutions to isotonic saline. While isotonic saline can cause dilutional-hyperchloraemic acidosis, it appears to be a mild, transient side effect with no proven adverse clinical outcomes.

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Last Updated: Jun 6, 2026

A Modified Lean and Release Technique to Emphasize Response Inhibition and Action Selection in Reactive Balance
07:19

A Modified Lean and Release Technique to Emphasize Response Inhibition and Action Selection in Reactive Balance

Published on: March 19, 2020

Area of Science:

  • Anesthesiology
  • Critical Care Medicine
  • Nephrology

Background:

  • Fluid therapy choices impact acid-base balance.
  • Recent controversy surrounds balanced solutions versus isotonic saline.
  • Dilutional-hyperchloraemic acidosis is a key concern.

Purpose of the Study:

  • To review fluid therapy studies comparing balanced solutions and isotonic saline.
  • To clarify the acid-base effects of different fluid choices.
  • To evaluate clinical outcomes associated with fluid selection.

Main Methods:

  • Systematic review of fluid therapy studies.
  • Analysis of acid-base equilibrium changes.
  • Definition of key terms: dilutional-hyperchloraemic acidosis, isotonic saline, balanced solutions.

Main Results:

  • Dilutional-hyperchloraemic acidosis is a moderate, transient side effect of large-volume isotonic saline crystalloid administration.
  • This acidosis is minimized by using colloids.
  • No convincing evidence links dilutional-hyperchloraemic acidosis to adverse renal, coagulation, bleeding, transfusion, gastrointestinal, or mortality outcomes.

Conclusions:

  • Current evidence does not support changing fluid therapy to balanced colloid preparations.
  • Isotonic saline remains a viable option due to long-term use and lack of documented harm.
  • Further research on balanced solutions' outcomes is limited.