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Type 2 diabetes does not attenuate racial differences in coronary calcification

Alisha N Wade1, Sean Fedyna, Nehal N Mehta

  • 1Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, United States.

Diabetes Research and Clinical Practice
|November 12, 2010
PubMed

Insights

White race predicts higher coronary artery calcification (CAC) in type 2 diabetes patients compared to African Americans. This association was stronger in men and potentially influenced by metabolic factors in women.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • Coronary artery calcification (CAC) is a significant predictor of atherosclerotic cardiovascular disease (CVD).
  • Prevalence of CAC appears higher in White individuals than African Americans (AAs).
  • The impact of type 2 diabetes on this racial disparity in CAC is not well understood.

Purpose of the Study:

  • To investigate the relationship between race and CAC in patients with type 2 diabetes.
  • To determine if type 2 diabetes modifies the observed racial differences in CAC.
  • To analyze these associations stratified by gender.

Main Methods:

  • Multivariable analyses were conducted on 861 patients with type 2 diabetes.
  • Self-reported ethnicity and CAC scores were analyzed.
  • Analyses were stratified by gender, with 32% AA and 66.9% male participants.

Main Results:

  • African American (AA) race was associated with lower CAC scores in both men and women compared to White individuals.
  • This association persisted in men after adjusting for cardiovascular risk factors.
  • In women, adjustment for plasma triglycerides and HOMA-IR partially attenuated the association between AA race and CAC.

Conclusions:

  • White race is a strong predictor of CAC in individuals with type 2 diabetes, relative to AA race.
  • The association between race and CAC in women with type 2 diabetes may be less robust than in men.
  • Gender differences in metabolic risk factors might explain the attenuated association in women.
Abstract

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