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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Updated: Jun 6, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

Anemia, fatigue and aging.

L Balducci1

  • 1H Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Dr, Tampa, FL 33612, USA. balducci@moffitt.usf.edu

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|November 12, 2010
PubMed
Summary
This summary is machine-generated.

Anemia is common in older adults, especially those with cancer, due to factors like inflammation and nutrient deficiencies. Treating anemia in elderly cancer patients requires caution with erythropoietic stimulating agents (ESAs) due to potential risks.

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Area of Science:

  • Gerontology
  • Hematology
  • Oncology

Background:

  • Aging increases the risk of cancer and anemia, with these conditions often exacerbating each other.
  • Anemia is a frequent and severe complication in older individuals, particularly those with cancer.

Purpose of the Study:

  • To review the causes and consequences of anemia in older individuals.
  • To discuss the management of anemia in elderly cancer patients, focusing on risks associated with erythropoietic stimulating agents (ESAs).

Main Methods:

  • Literature review of causes and consequences of anemia in the aging population.
  • Analysis of risks and benefits of erythropoietic stimulating agents (ESAs) in older cancer patients.

Main Results:

  • Common causes of anemia in the elderly include chronic inflammation, iron deficiency, cobalamin deficiency, myelodysplasia, copper deficiency, hypothyroidism, and sarcopenia.
  • Anemia in older adults is linked to higher mortality, functional decline, dementia, falls, and increased chemotherapy toxicity.
  • Erythropoietic stimulating agents (ESAs) may promote cancer growth and thrombosis, necessitating careful use in chemotherapy patients with hemoglobin levels below 12 g/dL.

Conclusions:

  • Anemia is a significant comorbidity in aging and cancer, impacting health outcomes.
  • Management of anemia in older cancer patients requires a balanced approach, considering the risks of treatments like ESAs.