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The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
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Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
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Rethinking schizophrenia.

Thomas R Insel1

  • 1National Institute of Mental Health, Bethesda, Maryland 20892, USA. tinsel@mail.nih.gov

Nature
|November 12, 2010
PubMed
Summary
This summary is machine-generated.

Schizophrenia is a chronic disorder with unknown causes and limited treatment efficacy. Viewing it as a neurodevelopmental disorder offers new hope for prevention and cure within two decades.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Developmental Psychology

Background:

  • Schizophrenia affects 1% of the global population as a chronic, disabling mental disorder.
  • Despite a century of study, the etiology of schizophrenia remains elusive.
  • Current pharmacological treatments, used for decades, show limited improvement in long-term outcomes.

Observation:

  • Schizophrenia is increasingly conceptualized as a neurodevelopmental disorder.
  • Psychosis may represent a late-stage, potentially preventable phase of this neurodevelopmental process.

Findings:

  • Rethinking schizophrenia as a neurodevelopmental disorder represents a paradigm shift from historical perspectives.
  • This novel approach differs significantly from the century-old view of schizophrenia.

Implications:

  • This neurodevelopmental perspective offers renewed hope for developing effective prevention strategies.
  • It paves the way for potential cures for schizophrenia within the next twenty years.