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Possible lymphocyte effects on lactase expression by mouse jejunal enterocytes.
T C Savidge1, M W Smith, P J Kilshaw
1Department of Cell Biology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge.
Experimental Physiology
|January 1, 1990
Summary
Infection with the intestinal parasite Nematospiroides dubius temporarily reduces jejunal intraepithelial lymphocytes and boosts lactase activity in mice. This suggests immune responses normally suppress lactase expression.
Area of Science:
- Immunology
- Gastroenterology
- Parasitology
Background:
- Intestinal parasites can modulate host physiology.
- Lactase activity in enterocytes is crucial for carbohydrate digestion.
- Immune responses play a role in regulating intestinal functions.
Purpose of the Study:
- To investigate the impact of Nematospiroides dubius infection on jejunal intraepithelial lymphocyte numbers and lactase activity in mice.
- To explore the relationship between local immune reactions and lactase expression.
Main Methods:
- Mice were infected with the intestinal parasite Nematospiroides dubius.
- Jejunal intraepithelial lymphocyte counts were assessed.
- Lactase activity in the jejunum was measured.
- Changes were observed over time and compared to control groups.
Main Results:
- Jejunal intraepithelial lymphocyte numbers decreased during early infection.
- Lactase activity increased in the early stages of infection.
- Both parameters returned to control levels later in the infection course.
- These changes indicate a temporary suppression of immune responses.
Conclusions:
- The presence of Nematospiroides dubius temporarily suppresses local immune reactions in the jejunum.
- Suppressed immune responses are linked to increased lactase expression by mouse enterocytes.
- Local immune reactions normally play an inhibitory role in regulating lactase expression.