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Related Experiment Video

Updated: Jun 6, 2026

Patch Angioplasty in the Rat Aorta or Inferior Vena Cava
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Double patch technique for closing acute ventricular septal perforation.

Kazuki Hisatomi1, Kiyoyuki Eishi, Masayoshi Hamawaki

  • 1Department of Cardiovascular Surgery, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. kazuhisa12121212@yahoo.co.jp

General Thoracic and Cardiovascular Surgery
|November 12, 2010
PubMed
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This study shows a double patch closure technique effectively treats ventricular septal perforation (VSP) after acute myocardial infarction (AMI), with excellent long-term survival and no residual shunts. The method offers a promising approach for VSP management.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Medical Devices

Background:

  • Ventricular septal perforation (VSP) is a severe complication of acute myocardial infarction (AMI).
  • VSP often leads to rapid heart failure progression, necessitating urgent surgical repair.
  • Current treatment options carry significant risks and challenges.

Purpose of the Study:

  • To detail a double patch closure technique for VSP using equine pericardial patches.
  • To present surgical outcomes and evaluate the effectiveness of this VSP repair method.
  • To identify and discuss challenges encountered during the procedure.

Main Methods:

  • A retrospective review of nine patients undergoing VSP closure for AMI.
  • Utilized a double-layered equine pericardial patch for VSP repair.

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Last Updated: Jun 6, 2026

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  • Preserved the infarction area within the left ventricular cavity, avoiding necrotic tissue excision.

    • Main Results:

    • Achieved zero mortality within 30 days and no in-hospital deaths.
    • Demonstrated no residual shunts during a mean 4.5-year follow-up.
    • All patients survived with a New York Heart Association functional class II.

    Conclusions:

    • The equine pericardial double patch technique provides secure VSP closure.
    • The procedure is associated with short operating times, minimal blood loss, and brief cardiopulmonary bypass.
    • This technique shows potential for improving the prognosis of patients with VSP post-AMI.