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Bone morphogenic protein-7 serum level decreases significantly in patients with contrast-induced nephropathy

Murat Duranay1, Liviu Segall, Nihat Sen

  • 1Department of Internal Medicine, Section of Nephrology, Ankara Training and Research Hospital, Ankara, Turkey.

International Urology and Nephrology
|November 12, 2010
PubMed

Insights

Serum bone morphogenic protein-7 (BMP-7) levels significantly decrease in patients who develop contrast-induced nephropathy (CIN). This suggests BMP-7 may serve as a diagnostic biomarker for CIN.

Area of Science:

  • Nephrology
  • Biochemistry

Background:

  • Endogenous bone morphogenic protein-7 (BMP-7) reduction is linked to acute kidney injury.
  • Exogenous BMP-7 administration shows therapeutic potential for kidney function.
  • Contrast-induced nephropathy (CIN) remains a significant cause of acute kidney injury in hospitalized patients.

Purpose of the Study:

  • To investigate serum BMP-7 level changes in patients with chronic kidney disease and CIN.
  • To evaluate BMP-7 as a potential biomarker for CIN development.

Main Methods:

  • 45 adult patients with chronic kidney disease (serum creatinine ≥ 1.4 mg/dl) undergoing coronary angiography were enrolled.
  • Serum BMP-7 levels were measured pre-procedure and 48 hours post-procedure.
  • CIN was defined as a ≥0.25 mg/dl or 25% increase in serum creatinine within 72 hours.

Main Results:

  • CIN developed in 8 (17%) patients.
  • Patients who developed CIN showed a significant decrease in serum BMP-7 levels post-angiography (488.6 ± 56.8 to 356.4 ± 24.8, P = 0.01).
  • Serum BMP-7 levels remained unchanged in patients without CIN (444.6 ± 54.6 to 440.0 ± 53.9, P = 0.09).

Conclusions:

  • Serum BMP-7 levels significantly decrease in patients developing CIN after coronary angiography.
  • BMP-7 may serve as a diagnostic biomarker for CIN.
  • BMP-7 shows promise as a potential therapeutic agent for CIN.
Abstract

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