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Interstitial nephritis and autoimmune pancreatitis: a case report
Monika Merkle1, Hermann-Josef Gröne
1Nephrologie, Klinikum Traunstein, Cuno-Niggl-Straße 3, 83278 Traunstein, Germany. Monika.Merkle@med.uni-muenchen.de
International Urology and Nephrology
|November 12, 2010
Summary
Autoimmune pancreatitis and interstitial nephritis can occur together. Mycophenolate mofetil effectively treated this patient, suggesting its use for combined autoimmune conditions.
Area of Science:
- Nephrology
- Gastroenterology
- Immunology
Background:
- Autoimmune pancreatitis (AIP) is a rare pancreatic disorder.
- Interstitial nephritis (IN) is linked to autoimmune conditions.
- Steroids are the primary treatment for AIP.
Observation:
- A 69-year-old man with AIP developed kidney dysfunction, proteinuria, and hypertension.
- Renal biopsy revealed severe diffuse interstitial nephritis.
- Initial treatment with prednisone and ACE inhibitors yielded incomplete recovery.
Findings:
- Adding mycophenolate mofetil improved kidney function and resolved proteinuria.
- Steroid dosage was reduced while maintaining remission.
- This suggests a potential shared autoimmune etiology.
Implications:
- Mycophenolate mofetil may be effective for treating simultaneous AIP and IN.
- This offers a new therapeutic option for patients with co-occurring autoimmune diseases.
- Further research is warranted to confirm these findings.
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