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Transfusion has no effect on recurrence in hepatitis C after liver transplantation

M J Rice1, A Wendling, R J Firpi

  • 1Department of Anesthesiology, University of Florida College of Medicine, Gainesville, USA. mrice@anest.ufl.edu

Acta Anaesthesiologica Scandinavica
|November 12, 2010
PubMed

Insights

Intraoperative blood product transfusions, including red blood cells (RBCs) and platelets, did not impact survival or hepatitis C virus (HCV) recurrence in liver transplant patients. Transfusions did not affect disease recurrence or fibrosis progression post-transplant.

Area of Science:

  • Hepatology
  • Transplant Surgery
  • Immunology

Background:

  • Literature suggests blood product transfusions negatively affect liver transplant patient survival.
  • Investigated impact of intraoperative transfusions on survival for hepatitis C-related end-stage liver disease.
  • Analyzed disease recurrence and fibrosis progression as metrics.

Purpose of the Study:

  • To determine the impact of intraoperative red blood cell (RBC) and platelet transfusions on liver transplant patient survival.
  • To assess the effect of these transfusions on hepatitis C virus (HCV) recurrence and fibrosis progression.

Main Methods:

  • Retrospective study of 194 consecutive liver transplant patients with HCV.
  • Analyzed post-transplant hepatic biopsy data at 4 months and 1 year for HCV recurrence and fibrosis.
  • Examined patient survival data.

Main Results:

  • No significant effect of intraoperative RBC or platelet transfusion on 1- or 5-year patient survival.
  • No difference in HCV recurrence or hepatic fibrosis progression at 4 months or 1 year based on transfusion status.

Conclusions:

  • Intraoperative RBC or platelet transfusions did not impact survival in HCV-infected liver transplant patients.
  • Transfusions showed no effect on HCV recurrence or fibrosis progression.
  • Clinically indicated transfusions appear safe and do not significantly impact outcomes in this patient group.
Abstract

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