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Growth hormone secretion in Addison's disease.

J Crabbé, J C Henquin, A E Lambert

Annales D'Endocrinologie

|January 1, 1978

Summary

Growth hormone secretion is altered in Addison's disease. Idiopathic Addison's patients showed reduced growth hormone response to glucagon and L-DOPA compared to tuberculosis-induced cases.

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Area of Science:

Endocrinology
Metabolic disorders

Background:

Addison's disease, or primary adrenal insufficiency, affects hormone regulation.
Growth hormone (GH) secretion dynamics in Addison's disease are not fully understood.
Etiology may influence endocrine responses in Addison's disease.

Purpose of the Study:

To investigate growth hormone (GH) secretion in patients with Addison's disease.
To compare GH response to various stimuli based on the cause of Addison's disease.

Main Methods:

Administered thyrotropin-releasing hormone (TRH), adrenocorticotropic hormone (ACTH), glucagon, and L-DOPA to patients with Addison's disease.
Measured plasma GH concentrations following stimulation.
Differentiated between idiopathic/auto-immune and tuberculosis-induced Addison's disease.

Main Results:

TRH and ACTH elicited minimal GH changes regardless of Addison's disease etiology.
Glucagon and L-DOPA revealed a blunted mean GH response in idiopathic/auto-immune Addison's disease compared to tuberculosis-induced cases.
Etiology significantly impacts GH secretory capacity in response to certain stimuli.

Conclusions:

GH secretion patterns in Addison's disease are influenced by the underlying cause.
Glucagon and L-DOPA are useful stimuli for differentiating GH response based on Addison's etiology.
Further research into GH regulation in adrenal insufficiency is warranted.

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