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QT dispersion in childhood obstructive sleep apnoea syndrome

Anant Khositseth1, Palinee Nantarakchaikul, Teeradej Kuptanon

  • 1Faculty of Medicine, Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. alaks@diamond.mahidol.ac.th

Cardiology in the Young
|November 13, 2010
PubMed

Insights

QT dispersion and corrected QT dispersion are elevated in children with obstructive sleep apnea syndrome, particularly those who are obese. These findings suggest obesity is a key factor in increased arrhythmogenic risks in this population.

Area of Science:

  • Cardiology
  • Pediatrics
  • Sleep Medicine

Background:

  • QT dispersion and corrected QT dispersion are potential indicators of arrhythmogenic risk.
  • Childhood obstructive sleep apnea syndrome (OSAS) is a growing concern with potential cardiac implications.
  • The relationship between OSAS, obesity, and cardiac electrical activity in children requires further investigation.

Purpose of the Study:

  • To evaluate QT dispersion and corrected QT dispersion in children diagnosed with obstructive sleep apnea syndrome.
  • To compare these electrophysiological parameters between children with and without OSAS.
  • To determine the specific impact of obesity on QT dispersion and corrected QT dispersion in pediatric OSAS.

Main Methods:

  • Electrocardiography (ECG) was performed on 44 children with OSAS and 38 healthy controls.
  • QT and RR intervals were measured to calculate QT dispersion and corrected QT dispersion.
  • Statistical analyses were conducted to compare groups, including subgroup analysis for obesity.

Main Results:

  • Mean QT dispersion and corrected QT dispersion were significantly higher in children with OSAS compared to controls (p=0.014 and p=0.010, respectively).
  • Children with OSAS and obesity exhibited significantly increased QT dispersion and corrected QT dispersion compared to controls (p=0.009 and p=0.043, respectively).
  • No significant difference in QT dispersion or corrected QT dispersion was observed between children with OSAS without obesity and controls.

Conclusions:

  • QT dispersion and corrected QT dispersion are significantly increased in pediatric obstructive sleep apnea syndrome, especially when associated with obesity.
  • Obesity appears to be a critical factor contributing to elevated QT dispersion and corrected QT dispersion in children with OSAS.
  • These findings highlight the importance of assessing cardiac electrical stability in obese children with OSAS.

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