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Published on: July 10, 2014
Combined effect of paste containing casein phosphopeptide-amorphous calcium phosphate and fluoride on enamel lesions:
Kiyokazu Ogata1, Sachie Warita, Kisaki Shimazu
1Department of Pediatric Dentistry, School of Life Dentistry at Tokyo, Nippon Dental University, Tokyo, Japan. k-ogata@tky.ndu.ac.jp
Purpose:
The purpose of this study was to show through enamel remineralization that a combination of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and fluoride is better than fluoride alone when the processing time for remineralization is short.
Methods:
The bovine enamel slabs (n=28) were subjected to pH cycling for 4 days. Paste containing CPP-ACP and/or fluoride was applied for 30 minutes daily. The sections were observed using a polarizing microscope and microradiographs.
Results:
In the groups treated solely with sodium fluoride (NaF) solution, tissue loss on the enamel surface was observed. On the other hand, in the groups that had been treated with a mixture of the NaF solution and CPP-ACP, the enamel surface was maintained.
Conclusions:
These results show that casein phosphopeptide-amorphous calcium phosphate-containing paste has the ability to maintain the enamel surface; the combined use of CPP-ACP paste and fluoride enhances this ability, thereby reducing demineralization.
