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Updated: Jun 6, 2026

Gene Expression Analyses in Human Follicles
Published on: February 17, 2023
Concentrations of stromal cell-derived factor-1 and vascular endothelial growth factor in relation to the diameter of
Akemi Nishigaki1, Hidetaka Okada, Rika Okamoto
1Department of Obstetrics and Gynecology, Kansai Medical University, Osaka, Japan.
Objective:
To determine the concentrations of stromal cell-derived factor-1 (SDF-1/CXCL12) and vascular endothelial growth factor (VEGF) in individual human preovulatory follicles in relation to their diameter or volume for clarifying the role of these molecules in folliculogenesis.
Design:
Prospective study.
Setting:
Research laboratory at Kansai Medical University.
Patient(S):
Twenty-seven women undergoing IVF.
Intervention(S):
Follicular fluid (FF) was collected from individual follicles. A total of 373 follicles were analyzed.
Main Outcome Measure(S):
The concentrations of SDF-1 and VEGF in FF and oocyte recovery rates.
Result(S):
The concentrations of SDF-1 and VEGF in follicles with a diameter ≤ 14 mm were significantly lower than those in follicles with a diameter ≥ 15 mm. The concentrations of SDF-1 and VEGF in FF increased with follicular diameters or volume, with concentrations peaking in follicles with a diameter of 18-20 mm or a volume of 3.6-5.0 mL. Furthermore, we found that there exists a positive correlation between the concentrations of SDF-1 and VEGF in FF from follicles ≤ 20 mm in diameter. The oocyte recovery rates increased with concentrations of SDF-1 and VEGF in FF.
Conclusion(S):
Our data suggest that SDF-1, as well as VEGF, may play an important role in follicular growth and development.
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