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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...

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Related Experiment Video

Updated: Jun 6, 2026

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
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Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles

Published on: May 14, 2021

Targeting c-FLIP in cancer.

Sarah Shirley1, Olivier Micheau

  • 1INSERM, U866, Dijon F-21079, France.

Cancer Letters
|November 13, 2010
PubMed
Summary

Cellular-FLICE inhibitory protein (c-FLIP) is a crucial regulator of apoptosis. Targeting c-FLIP offers a promising strategy to restore programmed cell death in cancer cells, enhancing therapeutic outcomes.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Cancer Research

Background:

  • Cellular-FLICE inhibitory protein (c-FLIP) is a critical regulator of apoptosis.
  • c-FLIP inhibits cell death pathways initiated by death receptors like Fas and TNF-R1.
  • Overexpression of c-FLIP is common in various cancers, contributing to treatment resistance.

Purpose of the Study:

  • To review the molecular mechanisms governing c-FLIP expression.
  • To explore current research on c-FLIP inhibitors for cancer therapy.
  • To highlight c-FLIP as a potential therapeutic target for restoring apoptosis in cancer.

Main Methods:

  • Literature review of molecular mechanisms controlling c-FLIP expression.
  • Analysis of current research on c-FLIP inhibitors.

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Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
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Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
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Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

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Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex

Published on: August 2, 2021

  • Synthesis of evidence supporting c-FLIP as a therapeutic target.

    • Main Results:

    • c-FLIP functions at the DISC to block caspase activation.
    • Downregulation of c-FLIP restores apoptosis induced by CD95L and TRAIL.
    • Multiple splice variants of c-FLIP exist, all impacting apoptosis.

    Conclusions:

    • c-FLIP is a key factor in cancer cell survival by inhibiting apoptosis.
    • Inhibiting c-FLIP presents a viable strategy to re-sensitize cancer cells to death-inducing signals.
    • Further investigation into c-FLIP inhibitors is warranted for effective cancer treatment.