Clinical findings and management of conjunctival intraepithelial neoplasia

Conjunctival intraepithelial neoplasia (CIN) is the most common tumor of the ocular surface and is a precursor to invasive squamous cell carcinoma. CIN comprises a spectrum of premalignant epithelial neoplasia that usually begins near the limbus and spreads to the cornea.

This case report reviews the clinical findings and management of CIN, with a discussion of the histopathology and etiology of this tumor.

CIN has a variety of clinical presentations, including gelatinous, leukoplakic, or papilliform. Because of their malignant potential, these lesions must be differentiated carefully and treated promptly. Traditional management of CIN is surgical excision with cryotherapy, but other topical treatments are being explored with promising results.