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Related Experiment Video

Updated: Jun 6, 2026

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
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Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

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Multispectral brain morphometry in Tourette syndrome persisting into adulthood.

Bogdan Draganski1, Davide Martino, Andrea E Cavanna

  • 1Département des Neurosciences Cliniques, CHUV, University of Lausanne, Switzerland. bogdan.draganski@gmail.com

Brain : a Journal of Neurology
|November 13, 2010
PubMed
Summary

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Adults with Tourette syndrome show reduced grey matter in frontal and temporal lobes, linked to symptom severity. Brain structure changes suggest ongoing plasticity and developmental abnormalities persist into adulthood.

Area of Science:

  • Neuroscience
  • Neuroimaging
  • Psychiatry

Background:

  • Tourette syndrome (TS) is a childhood-onset disorder often co-occurring with ADHD and OCD.
  • Structural brain alterations in frontostriatal circuits are noted in pediatric TS.
  • Limited research explores persistent structural changes in adult TS.

Purpose of the Study:

  • To investigate structural brain differences in adults with Tourette syndrome compared to healthy controls.
  • To examine the impact of co-morbidities and symptom severity on these structural changes.
  • To explore the relationship between grey matter volume, cortical thickness, and white matter integrity in adult TS.

Main Methods:

  • Utilized T1-weighted and diffusion-weighted MRI scans for 40 adults with TS and 40 matched controls.

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  • Employed cortical thickness estimation and voxel-based morphometry.
  • Analyzed white matter coherence and water diffusivity.

    • Main Results:

    • Adults with TS exhibited reduced grey matter volume in orbitofrontal, anterior cingulate, and ventrolateral prefrontal cortices.
    • Cortical thinning extended to the limbic mesial temporal lobe.
    • Prefrontal thinning correlated with tic severity; somatosensory cortex volume increase linked to premonitory sensation intensity.
    • Orbitofrontal cortex changes associated with abnormal grey matter water diffusivity.
    • White matter analysis revealed altered fibre coherence in the anterior corpus callosum, impacting cortico-cortical and cortico-subcortical tracts.

    Conclusions:

    • Findings support a neurodevelopmental model of Tourette syndrome with persistent frontostriatal alterations into adulthood.
    • Symptom severity correlates with structural changes, suggesting ongoing neuroplasticity.
    • Multimodal neuroimaging (volume, thickness, diffusivity) provides complementary insights into TS pathophysiology.