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The IMGT/HLA database.

James Robinson1, Kavita Mistry, Hamish McWilliam

  • 1Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK.

Nucleic Acids Research
|November 13, 2010
PubMed
Summary
This summary is machine-generated.

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The IMGT/HLA database provides curated human leukocyte antigen (HLA) sequences for researchers. This vital resource is regularly updated and publicly accessible online.

Area of Science:

  • Immunogenetics
  • Bioinformatics
  • Genomics

Background:

  • The Human Leukocyte Antigen (HLA) complex, located on chromosome 6p21.3, comprises over 220 genes, many crucial for immune function and exhibiting high polymorphism.
  • Accurate HLA gene and allele nomenclature and quality control are managed by the WHO Nomenclature Committee for Factors of the HLA System.

Purpose of the Study:

  • To provide the scientific and clinical communities with a continuously updated, searchable repository of curated HLA sequences.
  • To ensure public accessibility of critical HLA data through a dedicated web portal.

Main Methods:

  • Curating and maintaining a comprehensive database of HLA sequences.
  • Collaborating with the European Bioinformatics Institute for web accessibility.
  • Implementing regular updates to incorporate new and confirmed sequences.

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Main Results:

  • The IMGT/HLA database has been a key resource for 12 years, offering searchable, curated HLA sequences.
  • Public access to the database is provided via the http://www.ebi.ac.uk/imgt/hla/ website.
  • Regular updates ensure the HLA community receives the latest sequence information.

Conclusions:

  • The IMGT/HLA database is an essential, publicly accessible resource for HLA research.
  • Ongoing updates and curation ensure the database remains a reliable source for the immunology and genetics communities.
  • The collaborative effort facilitates the dissemination of critical HLA data worldwide.