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Related Experiment Videos

Plasma von Willebrand factor concentration and thyroid function in dogs.

S Avgeris1, C D Lothrop, T P McDonald

  • 1Department of Urban Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901.

Journal of the American Veterinary Medical Association
|March 15, 1990
PubMed
Summary

Hypothyroidism in dogs is linked to significantly lower von Willebrand factor:antigen levels. Treatment with thyroxine increased these levels, suggesting a connection between thyroid status and von Willebrand factor:antigen concentration.

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Area of Science:

  • Veterinary Medicine
  • Endocrinology
  • Hematology

Background:

  • Von Willebrand factor (vWF) is crucial for hemostasis.
  • Hypothyroidism is a common endocrine disorder in dogs.
  • Previous studies have not fully elucidated the relationship between canine hypothyroidism and vWF levels.

Purpose of the Study:

  • To investigate plasma von Willebrand factor:antigen concentrations in dogs with hypothyroidism.
  • To compare vWF levels in hypothyroid, hyperthyroid, and euthyroid dogs.
  • To assess the effect of thyroxine treatment on vWF levels in hypothyroid dogs.

Main Methods:

  • Quantification of plasma von Willebrand factor:antigen concentration using ELISA.
  • Comparison of vWF levels across three groups: suspected hypothyroidism, hyperthyroidism, and euthyroid controls.

Related Experiment Videos

  • Longitudinal assessment of vWF levels in a subset of hypothyroid dogs after one month of thyroxine therapy.

    • Main Results:

    • Mean vWF:antigen concentration was significantly reduced in hypothyroid dogs (47.1% +/- 12.6%) compared to euthyroid dogs (94.7% +/- 5.6%) (P < 0.0005).
    • Four hypothyroid dogs treated with thyroxine showed an increase in vWF:antigen concentration.
    • The single hyperthyroid dog exhibited a markedly elevated vWF:antigen concentration (200%).

    Conclusions:

    • Reduced plasma vWF:antigen concentration is associated with hypothyroidism in dogs.
    • Thyroid hormone replacement therapy may normalize vWF levels in hypothyroid dogs.
    • Acquired von Willebrand disease in dogs can be linked to hypothyroidism, distinct from congenital forms.