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Published on: July 19, 2018

Glycated hemoglobin predicts mortality in nondiabetic patients receiving chronic peritoneal dialysis

Kuan-Hsing Chen1, Ja-Liang Lin, Dan-Tzu Lin-Tan

  • 1Department of Nephrology and Division of Clinical Toxicology, Chang Gung Memorial Hospital, Lin-Kou Medical Center, Taipei, Taiwan, ROC.

American Journal of Nephrology
|November 13, 2010
PubMed

Insights

Glycemic status, measured by glycated hemoglobin (HbA1c), impacts mortality in nondiabetic patients undergoing chronic peritoneal dialysis (CPD). Both high and low HbA1c levels are associated with increased all-cause mortality risk over 18 months.

Area of Science:

  • Nephrology
  • Endocrinology
  • Clinical Medicine

Background:

  • Patients on chronic peritoneal dialysis (CPD) utilize glucose-based dialysate.
  • The influence of glycemic status on outcomes for nondiabetic CPD patients is not well-understood.

Purpose of the Study:

  • To investigate the association between glycated hemoglobin (HbA1c) levels and mortality in nondiabetic patients with CPD.
  • To identify glycemic control as a potential prognostic factor in this patient population.

Main Methods:

  • A prospective study involving 269 nondiabetic CPD patients.
  • Baseline HbA1c levels were measured and categorized into high, middle, and low tertiles.
  • Mortality and causes of death were tracked over an 18-month follow-up period.

Main Results:

  • Higher HbA1c levels correlated with older age, higher BMI, and increased peritoneal solute transport rate.
  • Cox multivariate analysis identified HbA1c as a significant risk factor for all-cause mortality.
  • Both high and low HbA1c tertiles were significantly associated with increased mortality compared to the middle tertile.

Conclusions:

  • Glycated hemoglobin (HbA1c) levels are linked to 18-month all-cause mortality in nondiabetic patients with CPD.
  • Both suboptimal high and low glycemic control, indicated by HbA1c, represent significant mortality risks.
Abstract

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